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We prove a microlocal lower bound on the mass of high energy eigenfunctions of the Laplacian on compact surfaces of negative curvature, and more generally on surfaces with Anosov geodesic flows. This implies controllability for the Schrödinger equation by any nonempty open set, and shows that every semiclassical measure has full support. We also prove exponential energy decay for solutions to the damped wave equation on such surfaces, for any nontrivial damping coefficient. These results extend previous works (see Semyon Dyatlov and Long Jin [Acta Math. 220 (2018), pp. 297–339] and Long Jin [Comm. Math. Phys. 373 (2020), pp. 771–794]), which considered the setting of surfaces of constant negative curvature. The proofs use the strategy of Semyon Dyatlov and Long Jin [Acta Math. 220 (2018), pp. 297–339 and Long Jin [Comm. Math. Phys. 373 (2020), pp. 771–794] and rely on the fractal uncertainty principle of Jean Bourgain and Semyon Dyatlov [Ann. of Math. (2) 187 (2018), pp. 825–867]. However, in the variable curvature case the stable/unstable foliations are not smooth, so we can no longer associate to these foliations a pseudodifferential calculus of the type used by Semyon Dyatlov and Joshua Zahl [Geom. Funct. Anal. 26 (2016), pp. 1011–1094]. Instead, our argument uses Egorov’s theorem up to local Ehrenfest time and the hyperbolic parametrix of Stéphane Nonnenmacher and Maciej Zworski [Acta Math. 203 (2009), pp. 149–233], together with the C 1 + C^{1+} regularity of the stable/unstable foliations. 

Network alignment plays an important role in a variety of applications. Many traditional methods explicitly or implicitly assume the alignment consistency which might suffer from over-smoothness, whereas some recent embedding based methods could somewhat embrace the alignment disparity by sampling negative alignment pairs. However, under different or even competing designs of negative sampling distributions, some methods advocate positive correlation which could result in false negative samples incorrectly violating the alignment consistency, whereas others champion negative correlation or uniform distribution to sample nodes which may contribute little to learning meaningful embeddings. In this paper, we demystify the intrinsic relationships behind various network alignment methods and between these competing design principles of sampling. Specifically, in terms of model design, we theoretically reveal the close connections between a special graph convolutional network model and the traditional consistency based alignment method. For model training, we quantify the risk of embedding learning for network alignment with respect to the sampling distributions. Based on these, we propose NeXtAlign which strikes a balance between alignment consistency and disparity. We conduct extensive experiments that demonstrate the proposed method achieves significant improvements over the state-of-the-arts. 

Abstract Although the governing equations of many systems, when derived from first principles, may be viewed as known, it is often too expensive to numerically simulate all the interactions they describe. Therefore, researchers often seek simpler descriptions that describe complex phenomena without numerically resolving all the interacting components. Stochastic differential equations (SDEs) arise naturally as models in this context. The growth in data acquisition, both through experiment and through simulations, provides an opportunity for the systematic derivation of SDE models in many disciplines. However, inconsistencies between SDEs and real data at short time scales often cause problems, when standard statistical methodology is applied to parameter estimation. The incompatibility between SDEs and real data can be addressed by deriving sufficient statistics from the time-series data and learning parameters of SDEs based on these. Here, we study sufficient statistics computed from time averages, an approach that we demonstrate to lead to sufficient statistics on a variety of problems and that has the secondary benefit of obviating the need to match trajectories. Following this approach, we formulate the fitting of SDEs to sufficient statistics from real data as an inverse problem and demonstrate that this inverse problem can be solved by using ensemble Kalman inversion. Furthermore, we create a framework for non-parametric learning of drift and diffusion terms by introducing hierarchical, refinable parameterizations of unknown functions, using Gaussian process regression. We demonstrate the proposed methodology for the fitting of SDE models, first in a simulation study with a noisy Lorenz ’63 model, and then in other applications, including dimension reduction in deterministic chaotic systems arising in the atmospheric sciences, large-scale pattern modeling in climate dynamics and simplified models for key observables arising in molecular dynamics. The results confirm that the proposed methodology provides a robust and systematic approach to fitting SDE models to real data. 

Abstract Gut microbiomes, such as the microbial community that colonizes the rumen, have vast catabolic potential and play a vital role in host health and nutrition. By expanding our understanding of metabolic pathways in these ecosystems, we will garner foundational information for manipulating microbiome structure and function to influence host physiology. Currently, our knowledge of metabolic pathways relies heavily on inferences derived from metagenomics or culturing bacteria in vitro. However, novel approaches targeting specific cell physiologies can illuminate the functional potential encoded within microbial (meta)genomes to provide accurate assessments of metabolic abilities. Using fluorescently labeled polysaccharides, we visualized carbohydrate metabolism performed by single bacterial cells in a complex rumen sample, enabling a rapid assessment of their metabolic phenotype. Specifically, we identified bovine-adapted strains of Bacteroides thetaiotaomicron that metabolized yeast mannan in the rumen microbiome ex vivo and discerned the mechanistic differences between two distinct carbohydrate foraging behaviors, referred to as “medium grower” and “high grower.” Using comparative whole-genome sequencing, RNA-seq, and carbohydrate-active enzyme fingerprinting, we could elucidate the strain-level variability in carbohydrate utilization systems of the two foraging behaviors to help predict individual strategies of nutrient acquisition. Here, we present a multi-faceted study using complimentary next-generation physiology and “omics” approaches to characterize microbial adaptation to a prebiotic in the rumen ecosystem.